The problem with this is that these issues are not saddle stitched (center stapled), but are stapled down through the page (sort of like oversewing with staples), at least in older giants.
In my O'Neill Shadow bind, I included a story from an 80 page giant (actually, it was a 100 pager, #259).I stripped the cover off the book and removed the staples, then pulled the pages I wanted and saved the rest for a future Batman miscellany book. The last page of the story had the first page of a decent reprint story on the back, so I did a color copy of that page and found a Batman/Shadow illustration by Kaluta on the back.