I imagine that Doctor Strange #1 will be reprinted in softcover again, I'm just waiting.

That said, I do believe there are certain titles that should just always be in print and available.  The Sun Also Rises, Catcher In The Rye, Pride and Prejudice all remain in print because they're classics...  I would think that having affordable editions of their core works available all the time would be an easy, low-risk way for Marvel to continue to grow new readers.  In a way I think that's what they're doing with the softcover MMWs, and as I said I expect any OOP volumes (of the classics-- FF, Spider-Man, Iron Man, Daredevil et al) to come back into print sometime--I just wish there wasn't so much of a lagtime between printings.

"I'm OMAC!  Evacuate this section!  I'm going to destroy it!"