I would keep the indie titles if you're enjoying them. Same for the 52 titles for now (seems you in general got the same bunch as I get digitally so you have good taste ;-)

I would drop Astonishing, Adjective-less X-Men and Legacy (after Carey exits) like a rock. See, that's the first 3. And I would just stick with the main Spider-Man series (Avenging Spider-Man should have been a breather arc).